The American McGee's Alice Original Soundtrack refers to the in-game soundtrack of American McGee's Alice, which was composed by Chris Vrenna, of Nine Inch Nails fame. The soundtrack was released on October 16, 2001 by Six Degrees Records under the title American McGee's Alice Original Music Score, and features all twenty original compositions from the game, a previously unreleased theme, and a remix of Flying on the Wings of Steam.
Originally, Marilyn Manson was involved scoring the music for Alice, and his composition was described by American McGee as "very cool" and having "a very beautiful Beatles-in-their-harpsichord-and-Hookah-pipe-days-sound to it." Although Manson left the project early on, his contributions persisted into the final product, notably the influence of alchemy and the character of the Mad Hatter, whose adaptation was somewhat influenced by him. Although not contributing to the final soundtrack, Manson was thanked in the in-game file credits for "staying up with American on those long nights." The final score for Alice was written and performed by Chris Vrenna, with the help of guitarist Mark Blasquez and singer Jessicka Addams of Jack Off Jill and Scarling.
Most of the sounds used in the tracks were created using toy instruments, music boxes, clocks, and doors. Female voices were sampled and manipulated into nightmarish soundscapes, including instances of them laughing maniacally, screaming, crying, and singing in an eerie, childlike way in order to create an eerie-sounding choir. A couple of the tracks, including I'm Not Edible, features the melody of the chorus of a children's song, My Grandfather's Clock.