You probably won’t notice a Blood Rose until it sprouts to its towering size and begins hurling giant thorns at you. These projectiles move fairly fast and come in large clusters. Better to duck behind something than try to dodge each thorn. Up close, the Rose slashes with its ragged leaves. Ranged attacks are your only option. Take single shots as you peek out from behind barriers. The Blood Rose is rooted to the ground, so it can’t pursue or adjust position for a better shot.
—Alice strategy guide
Blood Roses are corrupt flowers who appear to despise Alice's appearance and attack her by shooting out red thorns from their petals. There is no real trick to defeating the roses, except for avoiding their first barrage of thorns. Afterwards, they will be lucky to even hit Alice. Walking up to the vicious flora will cause them to swipe at Alice. One throw of the Vorpal Blade kills them easily, and a shot from the mallet can kill them in three hits.